Fibrotic Diseases and Fibrosis Biomarkers

Relevance of Fibrosis

Yellowish eyes are a sign of problems with liver, viral infection or other disease.

Organ fibrosis is responsible for 50% of the morbidity and mortality of chronic diseases worldwide. Fibrosis is characterized by excess deposition of scar tissue (extracellular matrix, ECM) at the expense of functional tissue. Fibrosis results from chronic inflammation, in the body’s attempt to prevent organ disintegration of ‘wounds that do not heal’. Causes are multiple, including chronic infections, autoimmune or metabolic diseases. Ongoing fibrosis leads to progressive scarring and functional failure of the affected organ. Examples are liver cirrhosis, lung or kidney fibrosis, or arteriosclerosis with multiorgan involvement. To date, there are no approved antifibrotic therapies and no validated non-invasive fibrosis biomarkers.

Fatigue Syndrome and Long-COVID

Fatigue Syndrome, as a form of chronic fatigue, is based, like Long-COVID Syndrome, on severe damage to the mitochondria (mitochondrial damage) as a result of a chronic undersupply of oxygen. The loss of mitochondrial function is accompanied by corresponding damage in the cell.

Liver, colon and lung cancer

One of ImmuneNTech's principal goals is to develop efficient therapies for these cancer types for subsequent clinical translation.

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